A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins. ClpXP is an important target for drug development against infectious diseases. Although structures are...

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Bibliographic Details
Main Authors: Zev A Ripstein, Siavash Vahidi, Walid A Houry, John L Rubinstein, Lewis E Kay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
AAA+
protease
CryoEM
protein degradation
N. meningitidis
ClpXP
Online Access:https://elifesciences.org/articles/52158

Internet

https://elifesciences.org/articles/52158

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