A recessive Trim2 mutation causes an axonal neuropathy in mice

A recessive Trim2 mutation causes an axonal neuropathy in mice

We analyzed Trim2A/A mice, generated by CRISPR-Cas9, which have a recessive, null mutation of Trim2. Trim2A/A mice develop ataxia that is associated with a severe loss of cerebellar Purkinje cells and a peripheral neuropathy. Myelinated axons in the CNS, including those in the deep cerebellar nuclei...

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Bibliographic Details
Main Authors: Jian J. Li, Nicolas Sarute, Eunjoo Lancaster, Guliz Otkiran-Clare, Bani Medegan Fagla, Susan R. Ross, Steven S. Scherer
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Cerebellum
Axonal spheroids
Ataxia
Axonal degeneration
CMT
Charcot-Marie-tooth disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120301200

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http://www.sciencedirect.com/science/article/pii/S0969996120301200

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