A recessive Trim2 mutation causes an axonal neuropathy in mice
We analyzed Trim2A/A mice, generated by CRISPR-Cas9, which have a recessive, null mutation of Trim2. Trim2A/A mice develop ataxia that is associated with a severe loss of cerebellar Purkinje cells and a peripheral neuropathy. Myelinated axons in the CNS, including those in the deep cerebellar nuclei...
Main Authors: | Jian J. Li, Nicolas Sarute, Eunjoo Lancaster, Guliz Otkiran-Clare, Bani Medegan Fagla, Susan R. Ross, Steven S. Scherer |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-07-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996120301200 |
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