Intersubunit concerted cooperative and cis-type mechanisms modulate allosteric gating in two-pore-domain potassium channel TREK-2

Intersubunit concerted cooperative and cis-type mechanisms modulate allosteric gating in two-pore-domain potassium channel TREK-2

In response to diverse stimuli, two-pore-domain potassium channel TREK-2 regulates cellular excitability, and hence plays a key role in mediating neuropathic pain, mood disorders and ischemia through. Although more and more input modalities are found to achieve their modulations via acting on the ch...

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Bibliographic Details
Main Authors: Ren-Gong eZhuo, Peng ePeng, Xiao-Yan eLiu, Hai-Tao eYan, Jiang-Ping eXu, Jian-Quan eZheng, Xiao-Li eWei, Xiao-Yun eMa
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Allosteric Regulation
2-APB
Two-pore domain potassium channel
TREK-2
intersubunit interaction
concatenated dimer
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00127/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00127/full

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