MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients

MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients

Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown mechanisms. Recently, we identified Midkine as...

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Bibliographic Details
Main Authors: Niamat Khan, Lutz Binder, D. V. Krishna Pantakani, Abdul R. Asif
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
epigenetics
promoter assay
MPA
PI3K
midkine
AKT
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00438/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00438/full

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