Generation of bi-allelic MYBPC3 truncating mutant and isogenic control from an iPSC line of a patient with hypertrophic cardiomyopathy

Generation of bi-allelic MYBPC3 truncating mutant and isogenic control from an iPSC line of a patient with hypertrophic cardiomyopathy

MYBPC3 is the most frequently affected gene in hypertrophic cardiomyopathy (HCM), which is an autosomal-dominant cardiac disease caused by mutations in sarcomeric proteins. Bi-allelic truncating MYBPC3 mutations are associated with severe forms of neonatal cardiomyopathy. We reprogrammed skin fibrob...

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Bibliographic Details
Main Authors: Nele Warnecke, Bärbel M. Ulmer, Sandra D. Laufer, Aya Shibamiya, Elisabeth Krämer, Christiane Neuber, Sophia Hanke, Charlotta Behrens, Malte Loos, Julia Münch, Jirko Kühnisch, Sabine Klaassen, Thomas Eschenhagen, Monica Patten-Hamel, Lucie Carrier, Giulia Mearini
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121003366

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http://www.sciencedirect.com/science/article/pii/S1873506121003366

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