Large scale genomic reorganization of topological domains at the HoxD locus

Large scale genomic reorganization of topological domains at the HoxD locus

Abstract Background The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD genes in developing digits is control...

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Bibliographic Details
Main Authors: Pierre J. Fabre, Marion Leleu, Benjamin H. Mormann, Lucille Lopez-Delisle, Daan Noordermeer, Leonardo Beccari, Denis Duboule
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Genome Biology
Subjects:
Regulatory landscape
Chromatin organization
Gene regulation
Topologically associating domains
TAD
Enhancer
Online Access:http://link.springer.com/article/10.1186/s13059-017-1278-z

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http://link.springer.com/article/10.1186/s13059-017-1278-z

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