Systematic production of inactivating and non-inactivating suppressor mutations at the relA locus that compensate the detrimental effects of complete spot loss and affect glycogen content in Escherichia coli.

Systematic production of inactivating and non-inactivating suppressor mutations at the relA locus that compensate the detrimental effects of complete spot loss and affect glycogen content in Escherichia coli.

In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function hydrolase/synthetase SpoT. Here we report the construction of spoT null (ΔspoT) muta...

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Bibliographic Details
Main Authors: Manuel Montero, Mehdi Rahimpour, Alejandro M Viale, Goizeder Almagro, Gustavo Eydallin, Ángel Sevilla, Manuel Cánovas, Cristina Bernal, Ana Belén Lozano, Francisco José Muñoz, Edurne Baroja-Fernández, Abdellatif Bahaji, Hirotada Mori, Francisco M Codoñer, Javier Pozueta-Romero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4154780?pdf=render

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http://europepmc.org/articles/PMC4154780?pdf=render

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