Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection

Pathogenic agents can spread from an initial to a secondary site via the lymphatics. Here, using a mouse model of infection, the authors show that S. pyogenes readily transit through sequential lymph nodes within efferent lymphatics to reach the bloodstream and drive systemic infection, while remain...

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Bibliographic Details
Main Authors: Matthew K. Siggins, Nicola N. Lynskey, Lucy E. Lamb, Louise A. Johnson, Kristin K. Huse, Max Pearson, Suneale Banerji, Claire E. Turner, Kevin Woollard, David G. Jackson, Shiranee Sriskandan
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18454-0