Synergistic action of CB1 and 5-HT2B receptors in preventing pilocarpine-induced status epilepticus in rats

Synergistic action of CB1 and 5-HT2B receptors in preventing pilocarpine-induced status epilepticus in rats

Endocannabinoids (eCBs) and serotonin (5-HT) play a neuromodulatory role in the central nervous system. Both eCBs and 5-HT regulate neuronal excitability and their pharmacological potentiation has been shown to control seizures in pre-clinical and human studies. Compelling evidence indicates that eC...

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Bibliographic Details
Main Authors: Roberto Colangeli, Roberto Di Maio, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Giuseppe Di Giovanni
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Neurobiology of Disease
Subjects:
Status epilepticus
EEG
Cannabinoid receptors
Serotonin
Synergistic interactions
Endocannabinoid system
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300336

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http://www.sciencedirect.com/science/article/pii/S0969996119300336

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