Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance

Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance

Congenital generalized lipodystrophy 2 (CGL2) is characterized by loss of adipose tissue, insulin resistance and cognitive deficits and caused by mutation of BSCL2/seipin gene. Seipin deletion in mice and rats causes severe lipodystrophy, insulin resistance, and cognitive impairment. Hippocampal neu...

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Bibliographic Details
Main Authors: Huanxian Chang, Tingting Di, Ya Wang, Xianying Zeng, Guoxi Li, Qi Wan, Wenfeng Yu, Ling Chen
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Seipin
Tau phosphorylation
Peroxisome proliferator-activated receptor-γ (PPARγ)
GSK3β
Mammalian target of rapamycin (mTOR)
Insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300762

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http://www.sciencedirect.com/science/article/pii/S0969996119300762

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