Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance
Congenital generalized lipodystrophy 2 (CGL2) is characterized by loss of adipose tissue, insulin resistance and cognitive deficits and caused by mutation of BSCL2/seipin gene. Seipin deletion in mice and rats causes severe lipodystrophy, insulin resistance, and cognitive impairment. Hippocampal neu...
Main Authors: | Huanxian Chang, Tingting Di, Ya Wang, Xianying Zeng, Guoxi Li, Qi Wan, Wenfeng Yu, Ling Chen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-07-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996119300762 |
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