Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

Abstract Background Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-repositioning approach which exploits old drugs approved for non-cachexi...

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Bibliographic Details
Main Authors: Lin Zhou, Tong Zhang, Wei Shao, Ruohan Lu, Lin Wang, Haisheng Liu, Bin Jiang, Shiqin Li, Huiqin Zhuo, Suheng Wang, Qinxi Li, Caihua Huang, Donghai Lin
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Skeletal Muscle
Subjects:
Amiloride
Cancer cachexia
Muscle wasting
Exosome
Exosome-release inhibition
Online Access:https://doi.org/10.1186/s13395-021-00274-5

Internet

https://doi.org/10.1186/s13395-021-00274-5

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