Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice

Abstract Background An association between neuroinflammation and age-related neurologic disorders has been established but the molecular mechanisms and cell types involved have not been thoroughly characterized. Activity of the proinflammatory NLRP3 inflammasome is implicated in Alzheimer’s and Park...

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Bibliographic Details
Main Authors: Katharine M. von Herrmann, Faith L. Anderson, Eileen M. Martinez, Alison L. Young, Matthew C. Havrda
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
NLRP3 inflammasome
Astrogliosis
Cryopyrin-associated periodic syndromes
Online Access:http://link.springer.com/article/10.1186/s12974-020-01866-6

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http://link.springer.com/article/10.1186/s12974-020-01866-6

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