Overexpression of TGF-β Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans

Overexpression of TGF-β Inducible microRNA-143 in Zebrafish Leads to Impairment of the Glomerular Filtration Barrier by Targeting Proteoglycans

Background: TGF-β is known as an important stress factor of podocytes in glomerular diseases. Apart from activation of direct pro-apoptotic pathways we wanted to analyze micro-RNA (miRs) driven regulation of components involved in the integrity of the glomerular filtration barrier induced by TGF-β....

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Bibliographic Details
Main Authors: Janina Müller-Deile, Finn Gellrich, Heiko Schenk, Patricia Schroder, Jenny Nyström, Johan Lorenzen, Hermann Haller, Mario Schiffer
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Versican
Syndecan
Glycocalyx
micro-RNA-143
Podocytes
Zebrafish
Proteinuria
Glomerulus
Online Access:http://www.karger.com/Article/FullText/453142

Internet

http://www.karger.com/Article/FullText/453142

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