Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model

Fingolimod (FTY720-P) Does Not Stabilize the Blood–Brain Barrier under Inflammatory Conditions in an in Vitro Model

Breakdown of the blood-brain barrier (BBB) is an early hallmark of multiple sclerosis (MS), a progressive inflammatory disease of the central nervous system. Cell adhesion in the BBB is modulated by sphingosine-1-phosphate (S1P), a signaling protein, via S1P receptors (S1P1). Fingolimod phosphate (F...

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Bibliographic Details
Main Authors: Michael K. Schuhmann, Stefan Bittner, Sven G. Meuth, Christoph Kleinschnitz, Felix Fluri
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:International Journal of Molecular Sciences
Subjects:
FTY720-P
blood-brain barrier
rat brain microvascular endothelial cell culture
inflammation
tight junctions
Online Access:http://www.mdpi.com/1422-0067/16/12/26177

Internet

http://www.mdpi.com/1422-0067/16/12/26177

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