Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy

Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy

The induction of tumor-targeted, cytotoxic T lymphocytes has been recognized as a key component to successful immunotherapy. DPX-based treatment was previously shown to effectively recruit activated CD8+ T cells to the tumor. Herein, we analyze the unique phenotype of the CD8+ T cells recruited into...

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Bibliographic Details
Main Authors: Ava Vila-Leahey, Alecia MacKay, Liliana Portales-Cervantes, Genevieve M. Weir, Alexandra Merkx-Jacques, Marianne M. Stanford
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
combination immunotherapy
checkpoint inhibitors
t cell activation
cd8+ t cells
immunology
flow cytometry
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1782574

Internet

http://dx.doi.org/10.1080/2162402X.2020.1782574

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