Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells

Dendritic cells (DC) are sentinels of immunity, essential for homeostasis of T cell-dependent immune responses. Both functions of DC, initiation of antigen-specific T cell immunity and maintenance of tissue-specific tolerance originate from distinct stages of differentiation, immunogenic versus tole...

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Bibliographic Details
Main Authors: Mario eHubo, Bettina eTrinschek, Fanny eKryczanowsky, Andrea eTüttenberg, Kerstin eSteinbrink, Helmut eJonuleit
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00082/full