α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress

α-Tocopherol at Nanomolar Concentration Protects Cortical Neurons against Oxidative Stress

The aim of the present work is to study the mechanism of the α-tocopherol (α-T) protective action at nanomolar and micromolar concentrations against H2O2-induced brain cortical neuron death. The mechanism of α-T action on neurons at its nanomolar concentrations characteristic for brain extracellular...

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Bibliographic Details
Main Authors: Irina O. Zakharova, Tatiana V. Sokolova, Yulia A. Vlasova, Liubov V. Bayunova, Maria P. Rychkova, Natalia F. Avrova
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
brain cortical neurons
H2O2
α-tocopherol
nanomolar and micromolar concentrations
viability
reactive oxygen species
ERK1/2
Akt
protein kinase Cδ
Bax/Bcl-2 ratio
Online Access:http://www.mdpi.com/1422-0067/18/1/216

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http://www.mdpi.com/1422-0067/18/1/216

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