Aging: when the ubiquitin–proteasome machinery collapses
In mammalian cells, protein degradation is an essential and dynamic process that is crucial for survival, growth, differentiation and proliferation of cells. Tellingly, the majority of intracellular proteins are degraded via the ubiquitin–proteasome system (UPS). UPS-mediated protein degradation ser...
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| Format: | Article |
| Language: | English |
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AIMS Press
2017-05-01
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| Series: | AIMS Molecular Science |
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| Online Access: | http://www.aimspress.com/Molecular/article/1454/fulltext.html |