The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 receptor, GFRAL, is located in a subset of cholecystokin...

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Bibliographic Details
Main Authors: Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, Garron T Dodd, Frank Reimann, Fiona M Gribble, Emily C Beebe, James D Dunbar, Jesline T Alexander-Chacko, Dana K Sindelar, Tamer Coskun, Paul J Emmerson, Simon M Luckman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
GDF15
GFRAL
CCK
food intake
brainstem
cisplatin
Online Access:https://elifesciences.org/articles/55164

Internet

https://elifesciences.org/articles/55164

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