A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control

A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control

Complement Factor H (CFH), with 20 short complement regulator (SCR) domains, regulates the alternative pathway of complement in part through the interaction of its C-terminal SCR-19 and SCR-20 domains with host cell-bound C3b and anionic oligosaccharides. In solution, CFH forms small amounts of olig...

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Bibliographic Details
Main Authors: Orla M. Dunne, Xin Gao, Ruodan Nan, Jayesh Gor, Penelope J. Adamson, David L. Gordon, Martine Moulin, Michael Haertlein, V. Trevor Forsyth, Stephen J. Perkins
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
analytical ultracentrifugation
complement factor H
inflammation
molecular modelling
X-ray scattering
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.601895/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.601895/full

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