Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, first described in 2004 have now emerged as the most important genetic finding in both autosomal dominant and sporadic Parkinson's disease (PD). While a formidable research effort has ensued since the initial gene discovery, little is...

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Main Authors: H.L. Melrose, J.C. Dächsel, B. Behrouz, S.J. Lincoln, M. Yue, K.M. Hinkle, C.B. Kent, E. Korvatska, J.P. Taylor, L. Witten, Y.-Q. Liang, J.E. Beevers, M. Boules, B.N. Dugger, V.A. Serna, A. Gaukhman, X. Yu, M. Castanedes-Casey, A.T. Braithwaite, S. Ogholikhan, N. Yu, D. Bass, G. Tyndall, G.D. Schellenberg, D.W. Dickson, C. Janus, M.J. Farrer
Format: Article
Language:English
Published: Elsevier 2010-12-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Transgenic
Dopamine
Microdialysis
Neuropathology
Anxiety
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002342

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http://www.sciencedirect.com/science/article/pii/S0969996110002342

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