Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding

Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding

The oxidation of RNA has been implicated in the development of many diseases. Among the four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the formation of 8-oxo-7,8-dihydroguanosine (8-oxoG). Despite the limited knowledge about how cells regulate the detrimental effe...

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Bibliographic Details
Main Authors: Juan C. Gonzalez-Rivera, Asuka A. Orr, Sean M. Engels, Joseph M. Jakubowski, Mark W. Sherman, Katherine N. O'Connor, Tomas Matteson, Brendan C. Woodcock, Lydia M. Contreras, Phanourios Tamamis
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Polynucleotide phosphorylase (PNPase)
PNPase structure
PNPase recognition
RNA oxidation
8-oxo-7,8-dihydroguanosine
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019303435

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http://www.sciencedirect.com/science/article/pii/S2001037019303435

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