The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line.

Mutations in the copper (Cu) transporter gene ATP7B, the primary cause of Wilson disease (WD), result in high liver Cu and death of hepatocytes. Cu chelators and zinc salts are the two most important drugs used in the treatment of WD patients; however, the molecular mechanisms of the drugs with rega...

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Bibliographic Details
Main Authors: Gursimran Chandhok, Nadine Schmitt, Vanessa Sauer, Annu Aggarwal, Mohit Bhatt, Hartmut H J Schmidt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4044041?pdf=render