Variation in cell signaling protein expression may introduce sampling bias in primary epithelial ovarian cancer.

Although the expression of cell signaling proteins is used as prognostic and predictive biomarker, variability of protein levels within tumors is not well studied. We assessed intratumoral heterogeneity of protein expression within primary ovarian cancer. Full-length proteins were extracted from 88...

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Bibliographic Details
Main Authors: Gabriele Mittermeyer, Katharina Malinowsky, Christian Beese, Heinz Höfler, Barbara Schmalfeldt, Karl-Friedrich Becker, Stefanie Avril
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3810127?pdf=render