Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra<sup>®</sup>, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra<sup>®</sup>, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

<p>Abstract</p> <p>Background</p> <p>Ezatiostat hydrochloride liposomes for injection, a glutathione S-transferase P1-1 inhibitor, was evaluated in myelodysplastic syndrome (MDS). The objectives were to determine the safety, pharmacokinetics, and hematologic improvement...

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Bibliographic Details
Main Authors: Burris Howard, Williams Stephanie, Emanuel Peter, Piro Lawrence, Ochoa Leonel, Callander Natalie, Galili Naomi, Raza Azra, Faderl Stefan, Estrov Zeev, Curtin Peter, Larson Richard A, Keck James G, Jones Marsha, Meng Lisa, Brown Gail L
Format: Article
Language:English
Published: BMC 2009-05-01
Series:Journal of Hematology & Oncology
Online Access:http://www.jhoonline.org/content/2/1/20

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http://www.jhoonline.org/content/2/1/20

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