Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease. Gemcitabine (GEM) is used as the gold standard drug in PDAC treatment. However, due to its poor efficacy, it remains urgent to identify novel strategies to overcome resistance issues. In this context, an intens...

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Bibliographic Details
Main Authors: Stefania Forciniti, Elisa Dalla Pozza, Maria Raffaella Greco, Tiago Miguel Amaral Carvalho, Barbara Rolando, Giulia Ambrosini, Cristian Andres Carmona-Carmona, Raffaella Pacchiana, Daria Di Molfetta, Massimo Donadelli, Silvia Arpicco, Marta Palmieri, Stephan Joel Reshkin, Ilaria Dando, Rosa Angela Cardone
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic ductal adenocarcinoma
cancer stem cells
3D organotypic cultures
gemcitabine
prodrug
extracellular matrix
Online Access:https://www.mdpi.com/1422-0067/22/1/29

Internet

https://www.mdpi.com/1422-0067/22/1/29

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