Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway

Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway

Context Valeriana jatamansi Jones [syn. V. wallichii DC, (Valerianaceae)] (VJJ) is used to treat depression. Objective To explore the effects of total iridoids of VJJ extract (TIV) on chronic unpredictable mild stress (CUMS) in mice. Materials and methods VJJ roots and rhizomes were extracted with 7...

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Bibliographic Details
Main Authors: Li Zhang, Liwen Wang, Li Huang, Yanni Zhao, Hongling Ding, Binglong Li, Lingmiao Wen, Wei Xiong, Yanjun Liu, Tinglan Zhang, Liudai Zhang, Lanlan Wu, Qing Xu, Yuqing Fan, Guihua Wei, Qiaozhi Yin, Yunhui Chen, Tiane Zhang, Zhiyong Yan
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
depression
blood–brain barrier (bbb) permeability
firmicutes
lactobacillus
bacteroidetes
functional prediction
Online Access:http://dx.doi.org/10.1080/13880209.2021.1944222

Internet

http://dx.doi.org/10.1080/13880209.2021.1944222

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