Caspase-1 initiates apoptosis in the absence of gasdermin D

Caspase-1 initiates apoptosis in the absence of gasdermin D

In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.

Bibliographic Details
Main Authors: Kohsuke Tsuchiya, Shinsuke Nakajima, Shoko Hosojima, Dinh Thi Nguyen, Tsuyoshi Hattori, Thuong Manh Le, Osamu Hori, Mamunur Rashid Mahib, Yoshifumi Yamaguchi, Masayuki Miura, Takeshi Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, Toshihiko Shiroishi, Takashi Suda
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09753-2

Internet

https://doi.org/10.1038/s41467-019-09753-2

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