A Theoretical and Experimental Study to Optimize Cell Differentiation in a Novel Intestinal Chip

A Theoretical and Experimental Study to Optimize Cell Differentiation in a Novel Intestinal Chip

Microphysiological systems have potential as test systems in studying the intestinal barrier, in which shear stress is critical for the differentiation of Caco-2 cells into enterocytes. The most commonly used in vitro gut model for intestinal barrier studies is based on trans-well cultures. Albeit u...

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Bibliographic Details
Main Authors: Nicky Langerak, Haysam M. M. Ahmed, Yang Li, Igor R. Middel, Hossein Eslami Amirabadi, Jos Malda, Rosalinde Masereeuw, René van Roij
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
gut-on-chip
shear stress
cell differentiation
3D printing
numerical computation
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00763/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00763/full

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