TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer

TNFR2/BIRC3-TRAF1 signaling pathway as a novel NK cell immune checkpoint in cancer

Natural Killer (NK) cells control metastatic dissemination of murine tumors and are an important prognostic factor in several human malignancies. However, tumor cells hijack many of the NK cell functional features compromising their tumoricidal activity. Here, we show a deleterious role of the TNFα/...

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Bibliographic Details
Main Authors: Alexandre Ivagnès, Meriem Messaoudene, Gautier Stoll, Bertrand Routy, Aurélie Fluckiger, Takahiro Yamazaki, Kristina Iribarren, Connie P. M. Duong, Laetitia Fend, Anne Caignard, Isabelle Cremer, Axel LeCesne, Julien Adam, Charles Honoré, Olivier Mir, Loïc Chaigneau, Anne Berger, Pierre Validire, Christos Christidis, Valérie Le Brun-Ly, Mark J. Smyth, Xavier Mariette, Benoît L. Salomon, Guido Kroemer, Sylvie Rusakiewicz, Laurence Zitvogel
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:OncoImmunology
Subjects:
nk cells
cancer
immunity
immune checkpoint
tnfα
birc3
traf1
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1386826

Internet

http://dx.doi.org/10.1080/2162402X.2017.1386826

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