Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein

Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein

Hepatocellular carcinoma (HCC) has emerged as one of the most prevalent life‐threatening cancers, and the high mortality rate is largely due to the metastasis. The sustained activation of Smad4 and transforming growth factor‐β (TGF‐β) is closely associated with advanced HCC metastasis. However, the...

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Bibliographic Details
Main Authors: Tao Yuan, Zibo Chen, Fangjie Yan, Meijia Qian, Hong Luo, Song Ye, Ji Cao, Meidan Ying, Xiaoyang Dai, Renhua Gai, Bo Yang, Qiaojun He, Hong Zhu
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Molecular Oncology
Subjects:
deubiquitinating enzyme
hepatocellular carcinoma
metastasis
Smad4
USP10
Online Access:https://doi.org/10.1002/1878-0261.12596

Internet

https://doi.org/10.1002/1878-0261.12596

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