Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance

Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance

Abstract Background Artemisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infections worldwide, but artemisinin resistance has risen rapidly in Southeast Asia over the past decade. Mutations in the kelch13 gene have been implicated in this resistance. We u...

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Bibliographic Details
Main Authors: Gustavo C. Cerqueira, Ian H. Cheeseman, Steve F. Schaffner, Shalini Nair, Marina McDew-White, Aung Pyae Phyo, Elizabeth A. Ashley, Alexandre Melnikov, Peter Rogov, Bruce W. Birren, François Nosten, Timothy J. C. Anderson, Daniel E. Neafsey
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Genome Biology
Subjects:
Malaria
Drug resistance
Genomics
Surveillance
Epistasis
Online Access:http://link.springer.com/article/10.1186/s13059-017-1204-4

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http://link.springer.com/article/10.1186/s13059-017-1204-4

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