l-Proline-Catalysed One-Pot Regio- and Diastereoselective Synthesis of Spiro[pyrido[2,3-d]pyrimidin-2-amine-6,5′-pyrimidines] in Water

l-Proline-Catalysed One-Pot Regio- and Diastereoselective Synthesis of Spiro[pyrido[2,3-d]pyrimidin-2-amine-6,5′-pyrimidines] in Water

Abstract A simple l-proline-catalysed regio- and diastereoselective synthesis of spiro[pyrido[2,3-d]pyrimidin-2-amine-6,5′-pyrimidines] in water through a strategy of one-pot multicomponent domino reaction of 2,6-diaminopyrimidin-4-one, aldehydes and barbituric acids is described. The notable advant...

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Bibliographic Details
Main Authors: Subarna Jyoti Kalita, Bidyut Das, Dibakar Chandra Deka
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2017-03-01
Series:SynOpen
Subjects:
spiro compounds
organocatalysis
multi-component reaction
l-proline
aqueous medium
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588456

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588456

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