Polygenic Scores Predict Alcohol Problems in an Independent Sample and Show Moderation by the Environment

Polygenic Scores Predict Alcohol Problems in an Independent Sample and Show Moderation by the Environment

Alcohol problems represent a classic example of a complex behavioral outcome that is likely influenced by many genes of small effect. A polygenic approach, which examines aggregate measured genetic effects, can have predictive power in cases where individual genes or genetic variants do not. In the...

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Bibliographic Details
Main Authors: Jessica E. Salvatore, Fazil Aliev, Alexis C. Edwards, David M. Evans, John Macleod, Matthew Hickman, Glyn Lewis, Kenneth S. Kendler, Anu Loukola, Tellervo Korhonen, Antti Latvala, Richard J. Rose, Jaakko Kaprio, Danielle M. Dick
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Genes
Subjects:
alcohol problems
adolescence
gene-by-environment
ALSPAC
FinnTwin12
Online Access:http://www.mdpi.com/2073-4425/5/2/330

Internet

http://www.mdpi.com/2073-4425/5/2/330

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