CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma

CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma

Checkpoint kinase 1 (CHK1) plays a key role in genome surveillance and integrity throughout the cell cycle. Selective inhibitors of CHK1 (CHK1i) are undergoing clinical evaluation for various human malignancies, including neuroblastoma. Recently, we reported that CHK1i, PF-477736, induced a p53-medi...

Full description

Bibliographic Details
Main Authors: Kiyohiro Ando, Verna Cázares-Ordoñez, Makoto Makishima, Atsushi Yokoyama, Yusuke Suenaga, Hiroki Nagase, Shinichi Kobayashi, Takehiko Kamijo, Tsugumichi Koshinaga, Satoshi Wada
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2020/2752417

Internet

http://dx.doi.org/10.1155/2020/2752417

Similar Items