Lack of N2-gene amplification on the Cepheid Xpert Xpress SARS-CoV-2 assay and potential novel causative mutations: A case series from Auckland, New Zealand

Lack of N2-gene amplification on the Cepheid Xpert Xpress SARS-CoV-2 assay and potential novel causative mutations: A case series from Auckland, New Zealand

We describe three cases with viral strains that demonstrate impaired N2-gene detection on the Cepheid Xpert Xpress SARS-CoV-2 assay, with two previously undescribed single nucleotide polymorphisms (SNPs): C29197T and G29227T. We propose that these SNPs are likely responsible since they are in close...

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Bibliographic Details
Main Authors: Shivani Fox-Lewis, Andrew Fox-Lewis, Jay Harrower, Richard Chen, Jing Wang, Joep de Ligt, Gary McAuliffe, Susan Taylor, Erasmus Smit
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:IDCases
Subjects:
COVID-19
SARS-CoV-2
PCR
Xpert
Mutations
Single nucleotide polymorphisms
Online Access:http://www.sciencedirect.com/science/article/pii/S221425092100189X

Internet

http://www.sciencedirect.com/science/article/pii/S221425092100189X

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