The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60

The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60

Background/Aims: The antileukemic potential of isoindigos make them desired candidates for understanding their mechanism of action. We have recently synthesized a novel group of pyridone-annelated isoindigos and identified the derivative 5'-Cl that is cytotoxic to various cancer cell lines. In...

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Bibliographic Details
Main Authors: Ayman M. Saleh, Ahmad Aljada, Mustafa M. El-Abadelah, Mutasem O. Taha, Salim S. Sabri, Jalal A. Zahra, Mohammad Azhar Aziz
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Pyridone-annelated isoindigo
Anticancer compound
Cell cycle
G0/G1 phase
Cyclin-D
Rb
CDK2
CDK4
Kinase activity
HL-60 cell line
Online Access:http://www.karger.com/Article/FullText/374003

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http://www.karger.com/Article/FullText/374003

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