Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency

Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency

Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin 2 gene transfer as single-agent therapy for insuli...

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Bibliographic Details
Main Authors: Mei Hua Gao, Dimosthenis Giamouridis, N. Chin Lai, Tracy Guo, Bing Xia, Young Chul Kim, Viet Anh Nguyen Huu, Dorota Skowronska-Krawczyk, Louise Lantier, Raag Bhargava, H. Kirk Hammond
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Gene therapy
Intravenous AAV8
Akita Mouse
Type 1 diabetes
Diabetic retinopathy
Insulin sensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119301482

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http://www.sciencedirect.com/science/article/pii/S2329050119301482

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