Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease driven in large part by accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product amyloid-β peptide (Aβ). However, AD is also characterised by reductions in secreted amyloid precursor protein-alpha (sAPP...

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Bibliographic Details
Main Authors: Valerie T. Y. Tan, Bruce G. Mockett, Shane M. Ohline, Karen D. Parfitt, Hollie E. Wicky, Katie Peppercorn, Lucia Schoderboeck, Mohamad Fairuz bin Yahaya, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Brain
Subjects:
Amyloid precursor protein
Lentivirus
Hippocampus
Memory
Long-term potentiation
Amyloid
Online Access:http://link.springer.com/article/10.1186/s13041-018-0348-9

Internet

http://link.springer.com/article/10.1186/s13041-018-0348-9

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