Overexpression of NPTX2 Promotes Malignant Phenotype of Epithelial Ovarian Carcinoma via IL6-JAK2/STAT3 Signaling Pathway Under Hypoxia

Overexpression of NPTX2 Promotes Malignant Phenotype of Epithelial Ovarian Carcinoma via IL6-JAK2/STAT3 Signaling Pathway Under Hypoxia

BackgroundEpithelial ovarian cancer (EOC) is the main subtype of ovarian cancer and shows an aggressive phenotype and poor prognosis. Neuronal pentraxin II (NPTX2) is a member of the neuronal pentraxin family and plays a contradictory role in different tumors. However, there has been no report about...

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Bibliographic Details
Main Authors: Xiaotian Han, Yechen Lu, Xiaoqi Li, Lingfang Xia, Hao Wen, Zheng Feng, Xingzhu Ju, Xiaojun Chen, Xiaohua Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
NPTX2
epithelial ovarian carcinoma (EOC)
IL6-JAK2/STAT3 signaling pathway
malignant phenotype
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.643986/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.643986/full

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