A comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells.

A comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells.

The non-receptor tyrosine kinase Src and receptor tyrosine kinase epidermal growth factor receptor (EGFR/ErbB1) have been established as collaborators in cellular signaling and their combined dysregulation plays key roles in human cancers, including breast cancer. In part due to the complexity of th...

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Bibliographic Details
Main Authors: Tomáš Helikar, Naomi Kochi, Bryan Kowal, Manjari Dimri, Mayumi Naramura, Srikumar M Raja, Vimla Band, Hamid Band, Jim A Rogers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3630219?pdf=render

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http://europepmc.org/articles/PMC3630219?pdf=render

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