Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity.

Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity.

Three observations have suggested that acid-sensing ion channels (ASICs) might be mammalian cutaneous mechanoreceptors; they are structurally related to Caenorhabditis elegans mechanoreceptors, they are localized in specialized cutaneous mechanosensory structures, and mechanical displacement generat...

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Bibliographic Details
Main Authors: Sinyoung Kang, Jun Ho Jang, Margaret P Price, Mamta Gautam, Christopher J Benson, Huiyu Gong, Michael J Welsh, Timothy J Brennan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3323639?pdf=render

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http://europepmc.org/articles/PMC3323639?pdf=render

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