Functional Insights From the Evolutionary Diversification of Big Defensins

Big defensins are antimicrobial polypeptides believed to be the ancestors of β-defensins, the most evolutionary conserved family of host defense peptides (HDPs) in vertebrates. Nevertheless, big defensins underwent several independent gene loss events during animal evolution, being only retained in...

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Bibliographic Details
Main Authors: Marco Gerdol, Paulina Schmitt, Paola Venier, Gustavo Rocha, Rafael Diego Rosa, Delphine Destoumieux-Garzón
Format: Article
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
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