Full-Profile Pharmacokinetic Study of High Dose Baclofen in Subjects With Alcohol Use Disorder

Full-Profile Pharmacokinetic Study of High Dose Baclofen in Subjects With Alcohol Use Disorder

Baclofen a gamma amino-butyric acid type B (GABA-B) receptor agonist, which has raised some interest for the treatment of alcohol use disorder (AUD), occasionally at dose up to 300 mg/d. We conducted the first full-profile pharmacokinetic study on baclofen in AUD subjects, up to the oral daily dose...

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Bibliographic Details
Main Authors: Nicolas Simon, Romain Moirand, Maurice Dematteis, Régis Bordet, Dominique Deplanque, Benjamin Rolland
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Psychiatry
Subjects:
baclofen
alcohol use disorder
pharmacokinetics
human
clinical trial
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00385/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2018.00385/full

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