Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity

Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity

Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE 12-28) as a promising endogenous peptide with antidepressan...

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Bibliographic Details
Main Authors: Alaeddine Djillani, Mariel Pietri, Sébastien Moreno, Catherine Heurteaux, Jean Mazella, Marc Borsotto
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
spadin-analogs
TREK-1 channel
PE 22-28
neurogenesis
synaptogenesis
antidepressant
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00643/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00643/full

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