Hematopoietic Prostaglandin D Synthase Inhibitor PK007 Decreases Muscle Necrosis in DMD <i>mdx</i> Model Mice

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness and wasting due to the lack of dystrophin protein. The acute phase of DMD is characterized by muscle necrosis and increased levels of the pro-inflammatory mediator, prostaglandin D2 (PGD2). Inhibiting the production of...

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Bibliographic Details
Main Authors: Sai Yarlagadda, Christina Kulis, Peter G. Noakes, Mark L. Smythe
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/11/9/994