Specificity of <i>Escherichia coli</i> Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography

Specificity of <i>Escherichia coli</i> Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography

Diarrhea caused by enterotoxigenic <i>Escherichia coli</i> (ETEC) is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile enterotoxin (LT), a close homologu...

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Bibliographic Details
Main Authors: Julie Elisabeth Heggelund, Joel Benjamin Heim, Gregor Bajc, Vesna Hodnik, Gregor Anderluh, Ute Krengel
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
bacterial toxin
cholera toxin
<i>Escherichia coli</i> heat-labile enterotoxin
lectin
<i>N</i>-acetyllactosamine binding
neutral glycosphingolipids
protein–carbohydrate interactions
surface plasmon resonance spectroscopy
X-ray crystal structure
Online Access:https://www.mdpi.com/1422-0067/20/3/703

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https://www.mdpi.com/1422-0067/20/3/703

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