m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

RNA modifications play critical roles in important biological processes. However, the functions of N6-methyladenosine (m6A) mRNA modification in cancer biology and cancer stem cells remain largely unknown. Here, we show that m6A mRNA modification is critical for glioblastoma stem cell (GSC) self-ren...

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Bibliographic Details
Main Authors: Qi Cui, Hailing Shi, Peng Ye, Li Li, Qiuhao Qu, Guoqiang Sun, Guihua Sun, Zhike Lu, Yue Huang, Cai-Guang Yang, Arthur D. Riggs, Chuan He, Yanhong Shi
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
m6A modification
METTL3
METTL14
FTO inhibitor
glioblastoma stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302747

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